Breakthrough Prize 2020: Winners

Recipients

1. Arthur L. Horwich, Franz-Ulrich Hartl

   Biology

   for discovering functions of molecular chaperones in mediating protein folding and preventing protein aggregation.

2. David Julius

   Biology

   for discovering molecules, cells, and mechanisms underlying pain sensation.

3. Jeffrey M. Friedman

   Biology

   for the discovery of a new endocrine system through which adipose tissue signals the brain to regulate food intake.

4. Virginia Man-Yee Lee

   Biology

   for discovering TDP43 protein aggregates in frontotemporal dementia and amyotrophic lateral sclerosis, and revealing that different forms of alpha-synuclein, in different cell types, underlie Parkinson's disease and Multiple System Atrophy.