Breakthrough Prize 2015: Winners

Recipients

1. Alim-Louis Benabid

   Biology

   for the discovery and pioneering work on the development of high-frequency deep brain stimulation (DBS), which has revolutionized the treatment of Parkinson's disease.

2. C. David Allis

   Biology

   for the discovery of covalent modifications of histone proteins and their critical roles in the regulation of gene expression and chromatin organization, advancing the understanding of diseases ranging from birth defects to cancer.

3. Jennifer A. Doudna

   Biology

   for harnessing an ancient mechanism of bacterial immunity into a powerful and general technology for editing genomes, with wide-ranging implications across biology and medicine.

4. Victor Ambros

   Biology

   for the discovery of a new world of genetic regulation by microRNAs, a class of tiny RNA molecules that inhibit translation or destabilize complementary mRNA targets.