Lasker Award 1999: Winners

Recipients

1. Albert Lasker Basic Medical Research Award

   Bertil Hille, Clay Armstrong, Roderick MacKinnon

   Biology

   For elucidating the functional and structural architecture of ion channel proteins, which govern the electrical potential of membranes throughout nature, thereby generating nerve impulses, and controlling muscle contraction, cardiac rhythm, and hormone secretion.

2. Lasker–DeBakey Clinical Medical Research Award

   David W. Cushman, Miguel Ondetti

   Biology

   For developing an innovative approach to drug design based on protein structure and using it to create the ACE inhibitors, powerful oral agents for the treatment of high blood pressure, heart failure, and diabetic kidney disease.

3. Lasker–Koshland Special Achievement Award in Medical Science

   Seymour S. Kety

   Biology

   For a lifetime of contributions to neuroscience— including discovery of a method for measuring cerebral blood flow that led to current brain imaging techniques, adoptive studies in schizophrenia that established its genetic origin, and visionary leadership in mental health that ushered psychiatry into the molecular era.