Alfred G. Knudson

Prix

1. 1997

   Prix international Canada Gairdner

   Biologie

   For his development of a two-hit mutational hypothesis for the origin of cancer that related hereditary and non-hereditary forms of retinoblastoma and other tumors; this hypothesis has become a paradigm for mutational theories on the origins of cancer and led directly to the concept of suppressor oncogenes.

2. 1998

   Prix Lasker — Prix Lasker-DeBakey pour la recherche médicale clinique

   Biologie

   For incisive studies in patient-oriented research that paved the way for identifying genetic alterations that cause cancer in humans and that allow for cancer diagnosis in patients at the molecular level.

3. 2004

   Prix Kyoto — Sciences fondamentales

   Biologie

   Seminal contribution to the establishment of the theory of the tumor suppressor gene in the mechanism of human carcinogenesis