Premio Internacional Canadá Gairdner 1997: Ganadores

Destinatarios

1. Alfred G. Knudson

   Biología

   For his development of a two-hit mutational hypothesis for the origin of cancer that related hereditary and non-hereditary forms of retinoblastoma and other tumors; this hypothesis has become a paradigm for mutational theories on the origins of cancer and led directly to the concept of suppressor oncogenes.

2. Corey S. Goodman

   Biología

   For his many contributions to development neurobiology, in particular for his initial cellular and subsequent molecular and genetic dissection of the mechanisms controlling the guidance of neuronal growth cones to find and recognize their correct targets.

3. Erkki Ruoslahti, Richard O. Hynes

   Biología

   For the discovery and characterization of the molecules responsible for cell-substrate adhesion including fibronections and integrins: and for recognizing the importance of extracellular matrix-cell interactions in modulating cell phenotype, and their clinical relevance in such fields as cancer, blood coagulation and wound healing.